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ABclonal Technology PerCP Mouse anti-Human CD3 mAb
Supplier: ABclonal Technology A26828500T
The protein encoded by this gene is the CD3-epsilon polypeptide which together with CD3-gamma -delta and -zeta and the T-cell receptor alpha beta and gamma delta heterodimers forms the T-cell receptor-CD3 complex This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways The genes encoding the epsilon gamma and delta polypeptides are located in the same cluster on chromosome 11 The epsilon polypeptide plays an essential role in T-cell development Defects in this gene cause immunodeficiency This gene has also been linked to a susceptibility to type I diabetes in women
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