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Medchemexpress LLC Pexidartinib hydrochloride | 2040295-03-0 | 99.8% | 454.28 | 10 G
Supplier: Medchemexpress LLC HY16749A10G
Pexidartinib hydrochloride is a potent, orally active, selective, and ATP-competitive inhibitor targeting the colony stimulating factor 1 receptor (CSF1R) and c-Kit. It demonstrates significant selectivity over other related kinases and is known to induce cell apoptosis, indicating anti-cancer activity. This compound has been shown to deplete microglia cells in mice and inhibit the proliferation of microglia. It also reduces tissue macrophage levels without affecting glucose homeostasis in mice.
- Potent and selective CSF1R and c-Kit inhibitor
- Orally active and ATP-competitive
- Exhibits 10- to 100-fold selectivity for CSF1R and c-Kit over related kinases
- Induces cell apoptosis
- Shows anti-cancer activity
- Depletes microglia cells in mice
- Inhibits proliferation of microglia
- Reduces tissue macrophage levels
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