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Medchemexpress LLC Pexidartinib hydrochloride | 2040295-03-0 | 99.8% | 454.28 | 5 G
Supplier: Medchemexpress LLC HY16749A5G
Pexidartinib hydrochloride (PLX-3397 hydrochloride) is a potent, orally active, selective, and ATP-competitive inhibitor of colony stimulating factor 1 receptor (CSF1R or M-CSFR) and c-Kit. It demonstrates significant selectivity over other related kinases and is known for inducing cell apoptosis and exhibiting anti-cancer activity.
- Potent, orally active, and selective inhibitor
- ATP-competitive CSF1R and c-Kit inhibitor
- IC50s of 20 nM for CSF1R and 10 nM for c-Kit
- Exhibits 10- to 100-fold selectivity over other related kinases
- Induces cell apoptosis
- Has anti-cancer activity
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