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Medchemexpress LLC Pexidartinib hydrochloride | 2040295-03-0 | 99.8% | 454.28 | 500 MG
SDP

Supplier:  Medchemexpress LLC HY16749A500MG

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Pexidartinib hydrochloride (PLX-3397 hydrochloride) is a potent, orally active, selective, and ATP-competitive colony stimulating factor 1 receptor (CSF1R or M-CSFR) and c-Kit inhibitor. It induces cell apoptosis and exhibits anti-cancer activity, making it a valuable tool for cancer research.

  • Potent, orally active, selective, and ATP-competitive inhibitor
  • Targets CSF1R (M-CSFR) with an IC50 of 20 nM and c-Kit with an IC50 of 10 nM
  • Exhibits 10- to 100-fold selectivity for these targets over other related kinases
  • Induces cell apoptosis and shows anti-cancer activity
  • Can deplete microglia cells in mice and reduces tissue macrophage levels
  • For research use only

Catalog No. 50-003-90721


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