Apexbio Technology LLC Pexmetinib (ARRY-614) 945614-12-0 100mg

Supplier:  Apexbio Technology LLC B6012100

Pexmetinib (ARRY-614 CAS 945614-12-0) is a small molecule inhibitor targeting both p38 mitogen-activated protein kinase (MAPK) and Tie2/Tek receptor tyrosine kinase It demonstrates in vitro IC50 values of 1000 ng/mL for Tie2 and 100 ng/mL for p38 MAPK and inhibits basal cytokine production in primary human bone marrow stromal cells with IC50 values between 50 100 nM In human whole blood assays it suppresses LPS-induced cytokine production (IC50 50 120 nM) and reduces IL-6 release in mouse models (ED50 10 mg/kg) Pexmetinib is studied for its impact on cytokine synthesis bone marrow biomarkers and inflammatory signaling highlighting its potential utility in hematologic and inflammatory research

Catalog No. 50-000-89358