Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Apexbio Technology LLC PF-03084014 865773-15-5 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A37115.1
PF-03084014 is a small-molecule inhibitor targeting -secretase It is designed to selectively inhibit -secretase activity thereby blocking the proteolytic cleavage of Notch receptors and regulating the Notch signaling pathway PF-03084014 exerts its biological activity primarily by preventing -secretase-mediated cleavage which inhibits the release of Notch intracellular domain (NICD) fragments and reduces Notch pathway signaling Based on these pharmacological properties PF-03084014 holds research potential in anticancer applications as evaluated in preclinical tumor models such as leukemia and pancreatic adenocarcinoma both as a single agent and in combination strategies
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?