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Apexbio Technology LLC PF-04929113 (SNX-5422) 908115-27-5 5mg
Supplier: Apexbio Technology LLC A40655
PF-04929113 (SNX-5422) [CAS 908115-27-5] is an orally bioavailable water-soluble prodrug of PF-04928473 designed as an inhibitor of heat shock protein 90 (Hsp90) Following oral administration PF-04929113 is rapidly absorbed and converted to its active form PF-04928473 This active metabolite facilitates degradation of HER2 client proteins and demonstrates pronounced antitumor effects in xenograft models including BT-474 and H1650 with minimal observed toxicity at effective doses PF-04928473 additionally suppresses signaling pathways such as p-ERK and p-Akt and reduces angiogenesis markers supporting its use in research on cancer biology and anti-angiogenic strategies
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