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Cayman Chemical PF-04979064 10mg
Supplier: Cayman Chemical 3952710 MG
A dual inhibitor of PI3K and mTOR (Kis = 0.13, 0.111, 0.122, and 1.42 nM for PI3Kα, PI3Kγ, PI3Kδ, and mTOR, respectively); selective for PI3K and mTOR over a panel of 36 other kinases at 1 µM; inhibits phosphorylation of Akt in BT-20 cells (IC50 = 9.1 nM); reduces tumor volume by 88% in a U87MG glioblastoma mouse xenograft model at 40 mg/kg; increases alveolar epithelial cell apoptosis in a mouse model of COPD induced by PM2.5
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