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Medchemexpress LLC PF 05089771 | 1235403-62-9 | 99.9% | 100 MG
Supplier: Medchemexpress LLC HY12883100MG
PF 05089771 is a potent, orally active, and selective arylsulfonamide Nav1.7 inhibitor. It is currently being studied for its potential use in pain management and diabetic neuropathy.
- Potent, orally active, and selective arylsulfonamide Nav1.7 inhibitor
- IC50 values of 11 nM for hNav1.7, 12 nM for cynNav1.7, 13 nM for dogNav1.7, 171 nM for ratNav1.7, and 8 nM for musNav1.7
- More than 1000-fold selective over tetrodotoxin-resistant (TTX-R) Nav1.5 and Nav1.8 channels (IC50s >10 μM)
- Exhibits a range of selectivity over TTX-sensitive (TTX-S) channels (10-fold for Nav1.2 to 900-fold for Nav1.3 and Nav1.4)
- Blocks the majority of TTX-S current (75.5 ± 10.5%) at 30 nM, with complete block at 100 nM
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