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Medchemexpress LLC PF-3758309 | 898044-15-0 | 99.8% | 490.62 | 50 MG
SDP

Supplier:  Medchemexpress LLC 50MGHY13007

Encompass_Preferred

PF-3758309 (PF-03758309) is a potent, orally available, and reversible ATP-competitive inhibitor of PAK4 with a Kd of 2.7 nM and a Ki of 18.7 nM. It demonstrates the expected cellular functions of a PAK4 inhibitor and is intended for research use only.

  • Inhibits anchorage-independent growth
  • Induces apoptosis
  • Promotes cytoskeletal remodeling
  • Inhibits proliferation
  • Inhibits phosphorylation of the PAK4 substrate GEF-H1
  • Shows statistically significant tumor growth inhibition in HCT116 and A549 models

Catalog No. 50-003-66199


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