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Apexbio Technology LLC PF-4981517 1390637-82-7 10mg
Supplier: Apexbio Technology LLC A431110
PF-4981517 (CAS 1390637-82-7) also known as CYP3cide is a potent and time-dependent inhibitor selective for human cytochrome P450 3A4 (CYP3A4) Acting via mechanism-based inactivation it distinguishes CYP3A4 from closely related isoform CYP3A5 allowing for the delineation of each enzyme s contribution to drug metabolism As a cationic lipophilic molecule at physiological pH PF-4981517 may undergo non-specific breakdown with high microsomal protein concentrations potentially influencing its observed inhibitory potency This compound serves as a valuable tool for investigating the impact of CYP3A5 genetic variation on pharmacokinetics and the relative metabolism of CYP3A substrates in vitro
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