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Apexbio Technology LLC PF-5274857 1373615-35-0 5mg
Supplier: Apexbio Technology LLC A85005
PF-5274857 (CAS 1373615-35-0) is a potent and selective antagonist of the Smoothened (Smo) receptor a G protein-coupled component of the conserved Hedgehog (Hh) signaling pathway It inhibits Smo with an IC50 of 5 8 nM In cellular assays PF-5274857 completely suppresses Shh-induced Hh pathway activity as indicated by reduced Gli-dependent transcription in MEF cells In vivo PF-5274857 demonstrates antitumor effects in a mouse medulloblastoma model with an IC50 of 8 9 nM significantly inhibiting tumor growth and downregulating Gli1 and Gli2 expression in skin tissue This compound is utilized in studies of Hh pathway modulation and related oncogenic processes
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