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Medchemexpress LLC PF-562271 (hydrochloride) | 939791-41-0 | 98.10% | 543.95 | 5 MG
Supplier: Medchemexpress LLC HY204035MG
PF-562271 hydrochloride is a potent, ATP-competitive, and reversible inhibitor targeting FAK (Focal Adhesion Kinase) and Pyk2 (Proline-rich tyrosine kinase 2) kinases, with IC50 values of 1.5 nM and 13 nM, respectively.
- Potent, ATP-competitive, and reversible kinase inhibitor.
- Selectively targets FAK and Pyk2 kinases.
- Exhibits IC50s of 1.5 nM for FAK and 13 nM for Pyk2.
- Also inhibits CDK2/E, CDK5/p35, CDK1/B, and CDK3/E.
- Impairs cell viability in various cell lines, including Ewing sarcoma.
- Inhibits FAK phosphorylation in vivo in a dose-dependent manner.
- Demonstrates positive effects on bone tumors, including decreased tumor growth and deposition of new bone.
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