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Cayman Chemical PfDHODH-IN-1 10mg
Supplier: Cayman Chemical 3772810 MG
An irreversible PDHK inhibitor (IC50s 49 101 and 313 nM for PDHK1 PDHK2 and PDHK3 respectively) selective for PDHK1-3 over PDHK4 (IC50 10 UM) and 322 other kinases at 10 UM but does inhibit FAK in a cell-free assay but not in a cell-based assay increases ROS production and induces apoptosis in cancer cells with a high ECAROCR ratio reduces the level of glycolysis metabolites in NCI H929 multiple myeloma cells at 0.25 UM reduces tumor growth in an A549 mouse xenograft model
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