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Apexbio Technology LLC PFI 4 900305-37-5 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC B59735.1
PFI 4 (CAS 900305-37-5) is a cell-permeable potent and selective inhibitor of the BRPF1 bromodomain exhibiting a pIC50 of 7 1 and a pKd of 8 0 BRPF1 belongs to the BRPF family which serves as a scaffold for the assembly of MYST family histone acetyltransferase (HAT) complexes involved in chromatin remodeling and transcriptional regulation In BROMOscan assays PFI 4 demonstrates high selectivity for BRPF1 compared to other bromodomains Cellular protein interaction studies reveal that PFI 4 disrupts BRPF1 association with chromatin enabling detailed investigation of BRPF1 function in epigenetic regulation and development
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