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Apexbio Technology LLC PH-797804 586379-66-0 25mg
Supplier: Apexbio Technology LLC A830825
PH-797804 (CAS 586379-66-0) is a potent reversible ATP-competitive inhibitor of human p38 mitogen-activated protein kinase (MAPK) demonstrating selectivity for the p38 isoform with an IC50 of 26 nM and a Ki of 5 8 nM In cellular assays PH-797804 inhibits LPS-induced production of TNF- and IL-1 in monocytes in a concentration-dependent manner and blocks osteoclast formation induced by RANKL and M-CSF in primary rat bone marrow cells Oral administration in animal models reduces LPS-stimulated TNF- levels and suppresses chronic inflammation in arthritis models indicating utility for studying inflammatory and autoimmune mechanisms
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