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Apexbio Technology LLC PHA-848125 802539-81-7 10mg
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Supplier:  Apexbio Technology LLC A850110

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PHA-848125 (CAS 802539-81-7) is a small-molecule ATP-competitive inhibitor primarily targeting Cdk2/cyclin A with an IC50 of 45 nM It also inhibits other cyclin-dependent kinases including Cdk7/cyclin H Cdk4/cyclin D1 Cdk5/p35 Cdk2/cyclin E and Cdk1/cyclin B but with lower potency (IC50 values ranging from 0 15 to 0 398 M) In cellular studies PHA-848125 reduces hyperphosphorylated forms of retinoblastoma protein (pRb) and increases its hypophosphorylated state reflecting inhibition of CDK-mediated cell cycle progression In vivo oral administration suppresses A2780 ovarian tumor xenograft growth by up to 91% PHA-848125 is utilized in cell cycle and oncology research

Catalog No. 50-000-95867


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