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Cayman Chemical PhenamIlmethnsulfonate 10mg
Supplier: Cayman Chemical 1430810 MG
A TRPP3 inhibitor (IC50 = 140 nM); also inhibits ENaC (IC50 = 400 nM); decreases basal short-circuit currents in human and ovine bronchial epithelial cells (IC50s = 75 and 116 nM, respectively); inhibits potassium chloride-induced contractions in isolated rat endothelium-denuded aortic rings (EC50 = 6.76 µM) and increases contractile force in isolated rat right ventricular papillary muscles (EC50 = 16.98 µM); reduces pulmonary artery medial wall thickness and decreases right ventricular peak pressure in a rat model of chronic hypoxia-induced pulmonary hypertension at 15 and 30 mg/kg per day
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