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Medchemexpress LLC Phenol, 4-[3-[1,3-dihydro-5-(methylsulfonyl)-2H-isoindol-2-yl]-3-methylbutyl]-2-(1,1-dimethylethoxy)- | 1802632-22-9 | 99.0% | 431.59 | 25 MG
SDP

Supplier:  Medchemexpress LLC 25MGHY111669

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Zervimesine (CT1812) is an orally active and brain penetrant sigma-2 receptor antagonist with a Ki of 8.5 nM. It can be used for the research of Alzheimer's disease. It has the potential for research in Alzheimer's disease, including the reversal and prevention of amyloid beta oligomer-induced vesicular membrane trafficking in Sprague-Dawley rat neurons.

  • Orally active and brain penetrant sigma-2 receptor antagonist
  • Ki of 8.5 nM for sigma-2 receptor
  • Displaces and prevents Aβ oligomer binding in neurons and glia
  • Increases synaptic number and protein expression in neurons
  • Selectively reduces Aβ oligomer extracellular concentrations in transgenic hAPP/PS1 mice
  • Improves cognitive performance in transgenic Thy1 huAPPSwe/Lnd+ male mice
  • Appearance: Solid
  • Color: White to off-white

Catalog No. 50-004-39515


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