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Apexbio Technology LLC PhiKan 083 880813-36-5 5mg
Supplier: Apexbio Technology LLC A44815
PhiKan 083 (CAS 880813-36-5) is a small molecule that selectively binds to the Y220C mutant form of the tumor suppressor protein p53 This mutation creates a surface crevice that compromises protein stability leading to increased denaturation rates PhiKan 083 interacts with this cavity exhibiting an approximate dissociation constant (Kd) of 125 10 M and Ki near 150 M and stabilizes the mutant protein in vitro by significantly extending its half-life at physiological temperature By targeting a non-functional protein region PhiKan 083 serves as a lead compound for modulating mutant p53 stability and is commonly employed in studies investigating pharmacological rescue strategies for oncogenic p53 Y220C variants No in vivo or clinical data are currently available
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