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Medchemexpress LLC PhiKan 083 hydrochloride | 1050480-30-2 | 99.3% | 274.79 | 10 MG
SDP

Supplier:  Medchemexpress LLC HY108637A100MG

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PhiKan 083 hydrochloride is a carbazole derivative designed to bind to the surface cavity and stabilize the Y220C p53 mutant, with a binding affinity (Kd) of 167 μM. It effectively slows down the thermal denaturation rate of the p53 mutant and has been shown to reduce cell viability in engineered variants of Ln229 cells. When used in combination with NSC 123127, it enhances pro-apoptotic activity across multiple Ln229 cell variants.

  • Binds to and stabilizes Y220C p53 mutant
  • Slows down thermal denaturation rate of p53 mutant
  • Reduces cell viability in engineered variants of Ln229 cells
  • Enhances pro-apoptotic activity when combined with NSC 123127

Catalog No. 50-003-44872


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