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Abcam Phortress, Antitumor agent, 50MG
Supplier: Abcam AB14463850MG
MW 459.4 Da, Purity >98%. Potent antitumor agent (IC₅₀ values for MCF-7 and MDA468 cells are 40 nM and 158 nM, respectively). Active against breast, ovarian and renal carcinomas. Taken up into sensitive cells followed by aryl hydrocarbon receptor binding and translocation into the nucleus. Requires metabolic activation by cytochrome P450 to generate cytotoxic species. Active in vitro and in vivo. Water soluble.
The product is subject to the following: Abcam Restricted Use Statement
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