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ABclonal Technology Phospho-p38 MAPK-T180/Y182
Supplier: ABclonal Technology AP1502100UL
The protein encoded by this gene is a member of the MAP kinase family MAP kinases act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation differentiation transcription regulation and development This kinase is activated by various environmental stresses and proinflammatory cytokines The activation requires its phosphorylation by MAP kinase kinases (MKKs) or its autophosphorylation triggered by the interaction of MAP3K7IP1 TAB1 protein with this kinase The substrates of this kinase include transcription regulator ATF2 MEF2C and MAX cell cycle regulator CDC25B and tumor suppressor p53 which suggest the roles of this kinase in stress related transcription and cell cycle regulation as well as in genotoxic stress response Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported
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