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Apexbio Technology LLC PI-103 371935-74-9 10mM (in 1mL DMSO)
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Supplier:  Apexbio Technology LLC A20675.1

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PI-103 (CAS 371935-74-9) is a selective inhibitor of class I phosphatidylinositol 3-kinases (PI3Ks) mechanistic target of rapamycin (mTOR) and DNA-dependent protein kinase (DNA-PK) It suppresses activity of p110 p110 p110 p110 mTOR and DNA-PK with IC50 values of 2 3 3 15 30 and 23 nM respectively PI-103 inhibits proliferation across multiple cancer cell lines including glioblastoma ovarian and prostate cancers It effectively reduces phosphorylation levels of AKT GSK3 p70S6K and S6RP thereby rendering it useful for studying PI3K/mTOR signaling pathways in oncology research

Catalog No. 50-000-62789


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