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Echelon Biosciences Research LabsSupplier Diversity Partner PI-103 (PI3-K alpha Inhibitor 1) 5 mg  DFS Item

Manufacturer:  Echelon Biosciences Research LabsSupplier Diversity Partner B03035MG

PI-103 is a selective inhibitor for the α-isoform of PI 3-Kinase (IC50: PI 3-Kα = 8 nM, PI 3-Kβ = 88 nM, PI 3-Kδ = 48 nM, PI 3-Kγ = 150 nM). It is also inhibits DNA-PK (IC50 = 2 nM) and mTOR1 and mTOR2 (IC50 = 20 & 83 nM). PI-103 shows little activity against a wide array of protein kinases at 10μM. PI-103 blocks glioma proliferation by blocking the PI 3-K/Akt pathway in vitro and in vivo.

Catalog No. 50-720-017


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