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Medchemexpress LLC Pi3k/akt-in-2 | 2684412-41-5 | 98.1% | 651.45 | 5 MG
SDP

Supplier:  Medchemexpress LLC HY1477685MG

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PI3K/AKT-IN-2 (Compound 12c) is identified as an inhibitor of PI3K and AKT. It has been shown to block epithelial-mesenchymal transition (EMT), induce apoptosis, and inhibit the polymerization of tubulin.

  • It is a PI3K and AKT inhibitor.
  • It blocks the epithelial-mesenchymal transition (EMT).
  • It induces apoptosis.
  • It inhibits the polymerization of tubulin.
  • It demonstrates antiproliferative activity against various cell lines (H460, MCF-7, A549, HGC-27, 293 T, and GES-1 cells) with specific IC50 values.
  • It suppresses the expressions/activities of matrix metalloprotease (MMP)-2 and vimentin, and up-regulates E-cadherin.
  • It induces significant up-regulation of CDK1 proteins expression while down-regulating cyclin B1 and Cdc25C.

Catalog No. 50-003-61546


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