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Medchemexpress LLC PI3K/mTOR Inhibitor-4 | 2361215-32-7 | 97.0% | 100 MG
Supplier: Medchemexpress LLC HY128333100MG
PI3K/mTOR Inhibitor-4 is an orally active pan-class I PI3K/mTOR inhibitor. It exhibits enzymatic inhibition activity for PI3Kα, PI3Kγ, PI3Kδ, and mTOR with IC50 values of 0.63 nM, 22 nM, 9.2 nM, and 13.85 nM, respectively. This inhibitor is suitable for cancer research and shows potent anti-proliferation activity in various cell lines.
- Orally active pan-class I PI3K/mTOR inhibitor
- Enzymatic inhibition of PI3Kα, PI3Kγ, PI3Kδ, and mTOR
- Suitable for cancer research
- Potent anti-proliferation activity in various cell lines
- Inhibits PI3K/AKT/mTOR pathway
- Low toxicity in PC12 and LO2 cells
- Decreases phosphorylation of AKT and S6 in Hela cells
- Favorable pharmacokinetic parameters in rats
- Effective in tumor xenograft models
- Soluble in DMSO (250 mg/mL)
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