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TARGETMOL CHEMICALS INC PICROPODOPHYLLOTOXIN 25MG
SDP

Supplier:  TARGETMOL CHEMICALS INC T3S0027

Encompass_Preferred

Also available in 1 mg 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Picropodophyllotoxin (AXL 1717) is a cyclolignan alkaloid found in the mayapple plant family (Podophyllum peltatum) and a small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF1R) with potential antineoplastic activity. Picropodophyllotoxin (AXL 1717) specifically inhibits the activity and downregulates the cellular expression of IGF1R without interfering with activities of other growth factor receptors such as receptors for insulin epidermal growth factor platelet-derived growth factor fibroblast growth factor and mast/stem cell growth factor (KIT). This agent shows potent activity in the suppression o f tumor cell proliferation and the induction of tumor cell apoptosis. IGF1R a receptor tyrosine kinase overexpressed in a variety of human cancers plays a critical role in the growth and survival of many types of cancer cells. purity: 99%

Catalog No. 50-258-0022


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