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Medchemexpress LLC Pictilisib (dimethanesulfonate) | 957054-33-0 | 99.7% | 705.85 | 1 ML
SDP

Supplier:  Medchemexpress LLC HY2018010MM/1ML

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Pictilisib dimethanesulfonate (GDC-0941 dimethanesulfonate) is a potent inhibitor of PI3Kα/δ with an IC50 of 3 nM, showing modest selectivity against p110β and p110γ. It effectively reduces tumor cell viability in breast cancer cell lines, inhibits Akt phosphorylation, and demonstrates strong antitumor activity in ZD1839-resistant non-small cell lung cancer lines. This compound also induces cell growth inhibition, G0-G1 arrest, and apoptosis in combination with U0126.

  • Potent PI3Kα/δ inhibitor (IC50: 3 nM)
  • Modest selectivity against p110β (11-fold) and p110γ (25-fold)
  • Reduces tumor cell viability in breast cancer cell lines
  • Inhibits Akt phosphorylation
  • Effective against ZD1839-resistant non-small cell lung cancer
  • Induces cell growth inhibition, G0-G1 arrest, and apoptosis in combination with U0126

Catalog No. 50-004-00704


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