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Apexbio Technology LLC Pifithrin-μ 64984-31-2 50mg
Supplier: Apexbio Technology LLC A448250
Pifithrin- (CAS 64984-31-2) is a cell-permeable small molecule that inhibits p53-mediated apoptosis by interfering with p53 s mitochondrial functions It directly disrupts the interaction between p53 and mitochondrial proteins such as Bcl-2 and Bcl-xL (Kd 0 82 mM for p53 Kd 0 80 mM for Bcl-xL) impeding p53 s role in apoptosis independent of its transcriptional activity In cell-based assays Pifithrin- (25 M) attenuated nutlin-3-induced apoptosis in ML-1 cells Additionally the compound selectively inhibits heat shock protein 70 (HSP70) activity and has been shown to protect murine thymocytes from DNA damage-induced injury Pifithrin- is widely used to investigate p53-dependent apoptosis and mitochondrial stress responses in biomedical research
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