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Medchemexpress LLC Pifithrin-α, p-nitro, cyclic | 60477-38-5 | 99.4% | 299.35 g/mol | C15H13N3O2S | 50MG
Supplier: Medchemexpress LLC HY12307650MG
Pifithrin-α, p-Nitro, Cyclic is a cell-permeable, active-form p53 inhibitor used in research to inhibit p53-dependent transcriptional activity and protect cells from p53-mediated apoptosis. It shows increased potency and a longer half-life compared with pifithrin-α, and demonstrates neuroprotective activity in etoposide-exposed cortical neurons (ED50 = 30 nM).
- Cell-permeable active-form p53 inhibitor.
- Higher potency than the parent compound; neuroprotective at low nanomolar concentrations.
- Acts via post-transcriptional inhibition of p53 without preventing S15 phosphorylation.
- High chemical purity suitable for research applications.
- Supplied in milligram-scale quantities for laboratory use.
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