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Cayman Chemical PIlsIcaInIdehydrochLRIde 100mg
SDP

Supplier:  Cayman Chemical 34242100 MG

Encompass_Preferred

A dual inhibitor of VEGFR and FGFR (IC50s 5-26 and 6-35 nM for VEGFR1-3 and FGFR1-4 respectively) selective for VEGFR1-3 and FGFR1-4 over a panel of 308 kinases at 1 UM inhibits PDGFRa PDGFRB and DDR1 (IC50s 35 169 and 6 nM respectively) as well as MAP4K4 MINK1 RET SIK2 YES1 and Tie2 (IC50s 49 41 8 23 152 and 174 nM respectively inhibits FGFR-dependent proliferation in H1581 lung SNU-16 stomach and RT4 bladder cancer cells (IC50s 104 132 and 192 nM respectively) and VEGF-induced tube formation by HUVECs (IC50 33 nM) decreases tumor volume in a RT4 mouse xenograft model at 20 and 40 mg/kg reduces tumor growth and intratumor phosphorylation of FGFR in a SNU-16 mouse xenograft model at 30 mg/kg

Catalog No. 50-294-9543


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