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Apexbio Technology LLC Pimasertib (AS-703026) 1236699-92-5 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A55735.1
Pimasertib (AS-703026 CAS 1236699-92-5) is a small molecule inhibitor targeting MEK1/2 within the MEK/ERK signaling pathway which is frequently dysregulated in cancer due to oncogenic mutations Pimasertib binds to a specific allosteric site on MEK inhibiting its activity independently of ATP and thus blocking downstream signaling involved in cell proliferation and survival In vitro Pimasertib demonstrates antiproliferative effects in tumor cell lines harboring activating mutations or gene amplifications in the MEK/ERK pathway with reported IC50 values ranging from 5 nM to 2 M In vivo oral administration in xenograft mouse models resulted in dose-dependent tumor growth inhibition Pimasertib is studied for its potential to modulate oncogenic MEK/ERK signaling in preclinical and clinical cancer research
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