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Apexbio Technology LLC Pitavastatin Calcium 147526-32-7 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A85045.1
Pitavastatin Calcium (CAS 147526-32-7) is a small molecule inhibitor primarily targeting the enzyme HMG-CoA reductase (HMGCR) thereby reducing the biosynthesis of LDL cholesterol Independent studies demonstrate that pitavastatin also decreases reactive oxygen species (ROS) generation in endothelial cells via NADPH oxidase suppression Additionally pitavastatin downregulates endothelial nitric oxide synthase (eNOS) mRNA expression yet enhances nitric oxide (NO)-dependent endothelial responses stimulated by acetylcholine or calcium ionophore A23187 Further research indicates that pitavastatin prevents cholesterol-mediated increases in calcium-activated potassium channel activity These properties make pitavastatin valuable for investigating cholesterol-related signaling pathways and cardiovascular physiology
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