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ABclonal Technology Pituitary homeobox 2 PITX2
Supplier: ABclonal Technology A22173100UL
This gene encodes a member of the RIEG PITX homeobox family which is in the bicoid class of homeodomain proteins The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression This protein plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes is involved in the development of the eye tooth and abdominal organs and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin Mutations in this gene are associated with Axenfeld-Rieger syndrome iridogoniodysgenesis syndrome and sporadic cases of Peters anomaly A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development Alternatively spliced transcript variants encoding distinct isoforms have been described
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