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Medchemexpress LLC PJ34 (hydrochloride) | 344458-15-7 | 99.8% | 331.80 | 1 ML
SDP

Supplier:  Medchemexpress LLC HY1368810MM/1ML

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PJ34 hydrochloride is an inhibitor of PARP1/2, with IC50 values of 110 nM for PARP1 and 86 nM for PARP2. It effectively inhibits PARP enzyme activity. In vitro, it attenuates cell death in PC12 cells, and in vivo studies show it significantly reduces cortical damage and decreases inflammatory mRNA levels in ischemic animals.

  • Inhibits PARP1 and PARP2 activity.
  • Attenuates cell death in PC12 cells.
  • Reduces cortical damage in vivo.
  • Decreases TNF-α mRNA levels.
  • Reduces E-selectin and ICAM-1 mRNA levels.

Catalog No. 50-003-48674


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