Medchemexpress LLC PKI-179 hydrochloride | 1463510-35-1 | 99.66% | 525.00 | 500 UG

Supplier:  Medchemexpress LLC HY11080A50MG

PKI-179 hydrochloride is a potent and orally active dual PI3K/mTOR inhibitor. It shows IC50s of 8 nM, 24 nM, 74 nM, 77 nM, and 0.42 nM for PI3K-α, PI3K-β, PI3K-γ, PI3K-δ, and mTOR, respectively. It also exhibits activity over E545K and H1047R, with IC50s of 14 nM and 11 nM, respectively. PKI-179 hydrochloride has demonstrated anti-tumor activity in vivo.

• Potent and orally active dual PI3K/mTOR inhibitor.
• Exhibits activity against various PI3K isoforms (PI3K-α, PI3K-β, PI3K-γ, PI3K-δ) and mTOR.
• Active against E545K and H1047R.
• Shows anti-tumor activity in vivo.
• Inhibits cell proliferation in MDA361 and PC3 cells.
• Good oral bioavailability (98% in nude mouse, 46% in rat, 38% in monkey, and 61% in dog) and a high half-life (>60 min).

Catalog No. 50-003-43233