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Apexbio Technology LLC Plerixafor 8HCl (AMD3100 8HCl) 155148-31-5 100mg
Supplier: Apexbio Technology LLC B1465100
Plerixafor 8HCl (AMD3100 8HCl) is a selective antagonist of the chemokine receptor CXCR4 functioning through inhibition of CXCL12 (SDF-1)-dependent signaling and chemotactic responses It acts by blocking CXCR4 activation and subsequent intracellular calcium mobilization induced by SDF-1 displaying IC50 values of approximately 27 3 nM (Ca flux) and 51 nM (chemotaxis) respectively Additionally plerixafor disrupts the binding interaction of radiolabeled SDF-1 with CXCR4-expressing cells This compound is commonly employed in biomedical research for studies targeting CXCR4-mediated cellular migration and signaling pathways involved in immunological processes and tumor biology
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