Cayman Chemical Plnt TurmerIc CurcumIn 50g

Supplier:  Cayman Chemical 8102550 G

A STING activator increases the levels of ROS and induces apoptosis in LL/2 cells at 2.5 UM induces cell cycle arrest at the S phase increases cytosolic levels of mitochondrial DNA and increases levels of phosphorylated Tbk1 Irf3 and STING in as well as increases secretion of 2'3'-cGAMP and ATP from LL/2 cells at 2.5 UM decreases tumor volume and weight and increases the percentage of intratumoral M1 macrophages and mature dendritic cells in an LL/2 mouse xenograft model at 2 mg/kg twice per day reduces lung weight and the number of lung metastases in wild-type and Sting1-/- mice in an LL/2 model of lung metastasis at 2.5 mg/kg twice per day increases serum levels of Ifn-B Ifn-Y Tnf-a and Cxcl10 as well as increases the percentage of intratumoral CD4 CD8 and CD38 T cells in wild-type mice and to a lesser extent in Sting1-/- mice in the same model at the same dose

Catalog No. 50-289-3893