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Apexbio Technology LLC PND-1186 1061353-68-1 10mg
Supplier: Apexbio Technology LLC A373010
PND-1186 (CAS 1061353-68-1) is a reversible ATP-competitive small molecule inhibitor of focal adhesion kinase (FAK) a cytoplasmic protein tyrosine kinase implicated in integrin- and growth-factor receptor-mediated signaling PND-1186 inhibits FAK enzymatic activity with an IC50 of 1 5 nM and suppresses autophosphorylation at Tyr-397 at approximately 0 1 1 M in various tumor cell lines thereby disrupting downstream signaling pathways involved in cell migration proliferation and survival In preclinical studies using breast and ovarian cancer models PND-1186 treatment reduces FAK phosphorylation inhibits tumor growth induces apoptosis and decreases metastatic activity highlighting its potential utility in cancer biology research
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