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Cayman Chemical PNU 112455A 10mg
Supplier: Cayman Chemical 3343810 MG
A calcium channel inhibitor inhibits PMCA in isolated and purified pig cardiac sarcolemma binds to a hydrophobic site on calcium-bound calmodulin (CaM) with a Kd value of 0.5 UM and inhibits CaM-activated cAMP PDE activity at 10-50 UM an effect that is negatively associated with the concentration of calmodulin shortens action potentials and decreases the inward calcium current in single guinea pig ventricular myocytes in the absence and presence of propranolol and phentolamine at 30 M decreases epinephrine serotonin and dopamine levels in rat brain at 50 mg/kg decreases epinephrine levels in rat heart protects anesthetized rats from coronary artery occlusion-induced arrhythmia at 0.5 mg/kg but increases mortality due to atrioventricular block leading to asystole at 5 mg/kg
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