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Apexbio Technology LLC PNU-120596 501925-31-1 200mg
Supplier: Apexbio Technology LLC B1615200
PNU-120596 (CAS 501925-31-1) is a selective type II positive allosteric modulator (PAM) of the 7 neuronal nicotinic acetylcholine receptor (nAChR) It enhances 7nAChR-mediated responses significantly increasing Ca2 -dependent signaling at 3 M in cell-based assays with an EC50 of 216 nM in SH-EP1 cells In Xenopus oocytes PNU-120596 augments agonist-induced currents and prolongs current duration The compound displays specificity for 7nAChRs over other nAChR subtypes and potentiates acetylcholine responses in rat hippocampal interneurons It also increases CREB phosphorylation and improves recognition memory in rodent models supporting its utility in neuropharmacological research on cholinergic signaling
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