AdipoGen Ponatinib

Supplier:  AdipoGen AGCR13538M005

Chemical. CAS 943319-70-8. Formula C29H27F3N6O. MW 532.6. Soluble in DMSO 30mg/ml, DMF 30mg/ml or ethanol 5mg/ml. Ponatinib is a potent multi-target kinase inhibitor with antiangiogenic and antineoplastic activities. It targets protein tyrosine kinases PTK, which catalyze the transfer of ATP-γ-phosphate to the tyrosine residues of the substrate proteins. Tyrosine kinase inhibitors TKIs compete with ATP for the ATP binding site of PTK and reduce tyrosine kinase phosphorylation, thereby inhibiting cancer cell proliferation. Ponatinib is an orally bioavailable Bcr-Abl tyrosine kinase inhibitor of native BCR-ABL IC50 = 0.37nM, the tyrosine kinase inhibitor-resistant mutant Bcr-AblT315I IC50 = 2nM, as well as Bcr-AblQ252H, Bcr-AblY253F, Bcr-AblM351T and Bcr-AblH396P mutants IC50s = 0.44, 0.3, 0.3, and 0.34nM, respectively in biochemical assays.

Catalog No. 50-256-2325