Medchemexpress LLC Porcn-IN-1 | 2036044-77-4 | 99.57% | 410.44 | 1 ML

Supplier:  Medchemexpress LLC HY11147210MM/1ML

Porcn-IN-1 is a potent porcupine inhibitor with an IC50 of 0.5±0.2 nM. It potently inhibits the secretion of Wnt3A, confirming its role as a porcupine inhibitor. Porcupine is an enzyme that catalyzes the addition of palmitoleate to a serine residue in Wnt proteins, a process essential for Wnt protein secretion. Porcn-IN-1 is as potent as the clinical compound LGK974 in a cell-based STF reporter gene assay.

• Potent porcupine inhibitor: IC50 of 0.5±0.2 nM.
• Confirmed inhibition: Potently inhibits the secretion of Wnt3A.
• Comparable to clinical compound: As potent as LGK974 in a cell-based STF reporter gene assay.
• Moderate clearance: Demonstrates moderate clearance in human and rat liver microsomes (57 mL/min/kg and 24 mL/min/kg respectively).
• High clearance in mouse microsomes: Exhibits high clearance in mouse microsomes (109 mL/min/kg).

Catalog No. 50-003-46475