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Medchemexpress LLC Porcn-IN-1 | 2036044-77-4 | 99.6% | 410.44 | 50 MG
Supplier: Medchemexpress LLC HY11147250MG
Porcn-IN-1 is a potent porcupine inhibitor with an IC50 of 0.5±0.2 nM. It potently inhibits the secretion of Wnt3A. Porcupine is an enzyme that catalyzes the addition of palmitoleate to a serine residue in Wnt proteins, a process required for their secretion.
- Potent porcupine inhibitor
- Inhibits secretion of Wnt3A
- Targets Porcupine and is involved in the Stem Cell/Wnt pathway
- As potent as clinical compound LGK974 in cell-based STF reporter gene assay
- Demonstrates moderate clearance in human and rat liver microsomes
- Exhibits high clearance with mouse microsomes
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