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Apexbio Technology LLC PPM-18 65240-86-0 25mg
Supplier: Apexbio Technology LLC C407425
PPM-18 (CAS 65240-86-0) is a synthetic naphthoquinone derivative that functions as an anti-inflammatory agent by inhibiting inducible nitric oxide synthase (iNOS) expression It exerts its effect by suppressing the activation of nuclear factor B (NF- B) as demonstrated by reduced nuclear translocation of NF- B subunits (p65 and p50) and an IC50 of 5 M for NF- B inhibition in vitro In cell models PPM-18 decreases nitrite production and attenuates iNOS mRNA and protein induction without directly inhibiting NOS enzymatic activity In animal studies PPM-18 confers protection against LPS-induced lethality and supports vascular stability This compound is valuable for investigating iNOS regulation NO-mediated signaling and inflammatory processes in cellular and in vivo models
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