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Medchemexpress LLC PPM-3 | 3032388-42-1 | 98.2% | 1000.26 | 5 MG
Supplier: Medchemexpress LLC HY1496165MG
PPM-3 is a potent and selective PROTAC ERK5 degrader with an IC50 of 62.4 nM. It does not directly influence tumor cell growth but affects tumor development by influencing the differentiation of macrophages.
- Potent and selective PROTAC ERK5 degrader
- IC50 of 62.4 nM
- Affects tumor development by influencing macrophage differentiation
- Initiates ERK5 degradation within 2-4 hours, with peak degradation at 12 hours
- Maintains ERK5 degradation for at least 72 hours
- Shows ERK5 degradation activity in multiple cancer cell lines including H1975, HepG2, MDA-MB-231, PC-3, HCT116, and A375
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