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Cayman Chemical -PraeruptrIn B 10mg
Supplier: Cayman Chemical 3753610 MG
A pyranocoumarin with diverse biological activities; inhibits RANKL-induced osteoclastogenesis of primary mouse BMDMs at 10 µM and LPS-induced NO production in RAW 264.7 macrophages at 100 µM; inhibits PAF-induced platelet aggregation in isolated rabbit platelet-rich plasma (IC50 = 50 µM) and contractions of isolated guinea pig ileum induced by histamine or leukotriene D4 (pD2s = 4.84 and 4.34, respectively); decreases ovariectomy-induced bone loss in a mouse model of osteoporosis at 10 mg/kg; reduces the number of tumors initiated by DMBA and promoted by TPA in a mouse two-stage model of skin carcinogenesis
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