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Medchemexpress LLC Pralsetinib | 2097132-94-8 | 533.60 | 1 ML
SDP

Supplier:  Medchemexpress LLC HY11230110MM/1ML

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Pralsetinib is a highly potent and selective RET inhibitor that effectively targets wild-type RET and various RET mutants, including V804L, V804M, M918T, and CCDC6-RET fusion. It demonstrates significantly increased potency compared to approved MKIs against oncogenic RET variants and resistance mutants, and suppresses RET pathway signaling in a range of RET-driven cell lines.

  • Highly potent and selective RET inhibitor
  • Targets wild-type RET and specific RET mutants (V804L, V804M, M918T) and fusions (CCDC6-RET)
  • Increased potency against oncogenic RET variants and resistance mutants
  • Suppresses RET pathway signaling in various RET-driven cell lines
  • Inhibits growth of NSCLC and thyroid cancer xenografts
  • Does not inhibit vascular endothelial growth factor receptor 2 (VEGFR-2)

Catalog No. 50-004-37720


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