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Medchemexpress LLC Pralsetinib | 2097132-94-8 | 533.60 | 25 MG
Supplier: Medchemexpress LLC 25MGHY112301
Pralsetinib (BLU-667) is a highly potent, selective RET inhibitor. It inhibits WT RET, RET mutants V804L, V804M, M918T and CCDC6-RET fusion with IC50s of 0.4, 0.3, 0.4, 0.4, and 0.4 nM, respectively. This compound demonstrates potent activity against common oncogenic RET alterations, including RET M918T and the CCDC6-RET fusion, suppressing RET pathway signaling in various cell lines.
- Highly potent and selective RET inhibitor.
- Inhibits various RET mutants and fusions with high efficacy.
- Effective against oncogenic RET alterations.
- Suppresses RET pathway signaling.
- Powder stable at -20°C for 3 years, 4°C for 2 years.
- In solvent stable at -80°C for 2 years, -20°C for 1 year.
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